Investigating how kidney injury affects lung inflammation
Official title: Role of circulating Osteopontin and of Innate Immune Cell CD44 in Tissue Injury-induced Remote Lung Inflammation
Funded at Washington University · NIH-11025597 · Data updated 2026-11-12
This study is looking at how kidney problems can affect the lungs and cause serious issues, and it aims to find out how a specific protein might help us understand and treat these complications better for patients with multiple organ issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $583,233 |
| NIH project number | 1R01HL177000-01 |
| Project ID | NIH-11025597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing acute kidney injury or those at risk of multiorgan failure.
✕Less likely to help
Patients with isolated lung or kidney conditions unrelated to multiorgan failure may not benefit from this research.
What this research studies
This research focuses on understanding the connection between acute kidney injury and lung inflammation, which can lead to serious complications in patients with multiorgan failure. The team aims to identify the role of a protein called osteopontin and its interactions with immune cells in the lungs. By studying how these interactions occur, the researchers hope to uncover new therapeutic strategies to prevent or treat lung complications that arise from kidney injury. Patients may benefit from insights gained into the mechanisms of organ crosstalk and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients suffering from multiorgan failure.
How similar studies have gone: Previous research has shown promising results in understanding organ interactions in multiorgan failure, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Herrlich, Andreas — Washington University
- Study coordinator: Herrlich, Andreas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.