Investigating how kidney injury affects lung damage
Role of NOD2 in Acute Lung Injury Following Ischemic Kidney Injury
This study is looking at how kidney damage can make lung problems worse in people who have both acute kidney injury and acute respiratory distress syndrome (ARDS), and it hopes to find new ways to help treat these patients by understanding the signals that injured kidneys send to the lungs.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10838508 on NIH RePORTER |
What this research studies
This research explores the connection between acute kidney injury and acute respiratory distress syndrome (ARDS), focusing on how kidney damage can worsen lung inflammation and injury. The study examines the role of specific molecules released from injured kidney cells that may trigger inflammatory responses in the lungs. By understanding these mechanisms, the research aims to identify potential therapeutic targets that could improve treatment options for patients suffering from both kidney and lung injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing acute respiratory distress syndrome, particularly those with a history of acute kidney injury.
Not a fit: Patients with chronic lung or kidney conditions that are not acute may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce mortality and improve recovery for patients with ARDS following kidney injury.
How similar studies have performed: Other research has shown promising results in understanding the kidney-lung interaction, but this specific approach focusing on NOD2 is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Dewolf, Sean Edward — University of California, San Diego
- Study coordinator: Dewolf, Sean Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.