Investigating how IRGM proteins control inflammation
IRGM proteins as regulators of inflammation
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10766745
This study is looking at how certain proteins in our body help control inflammation when we get infections, and it aims to find new ways to improve treatments for conditions like sepsis that involve too much inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10766745 on ClinicalTrials.gov |
What this research studies
This research explores the role of IRGM proteins in regulating inflammation, particularly in response to bacterial components. It aims to understand how these proteins influence immune responses by modulating the production of inflammatory cytokines in macrophages. The study will involve both in vitro experiments with human and mouse cells and in vivo assessments to evaluate the impact of IRGM proteins on conditions like sepsis. By examining metabolic pathways and immune signaling, the research seeks to uncover new mechanisms that could lead to better treatments for inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from inflammatory conditions like Crohn's disease or those at risk for sepsis.
Not a fit: Patients with non-inflammatory conditions or those not affected by immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory diseases such as Crohn's disease and sepsis.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune proteins in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAYLOR, GREGORY A — DUKE UNIVERSITY
- Study coordinator: TAYLOR, GREGORY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Crohn disease, Crohn's disorder