Investigating how intestinal exosomes contribute to liver injury from alcohol consumption
Intestinal exosomes in alcohol-induces liver injury
This study is looking at how tiny particles from the gut, called exosomes, might contribute to liver damage from binge drinking, and it’s inviting people with alcohol use disorder to share blood samples to help understand how these changes happen in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10883964 on NIH RePORTER |
What this research studies
This research explores the role of intestinal exosomes in the liver damage caused by binge drinking. It focuses on how specific microRNAs, particularly let-7b, are released from the intestine into the bloodstream during episodes of heavy alcohol use. By examining the interactions between these exosomes and liver cells, the study aims to uncover mechanisms that lead to liver inflammation and fatty liver disease. Patients with alcohol use disorder may provide blood samples to help identify the molecular changes associated with liver injury.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with alcohol use disorder who are experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have no liver-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools or treatments for liver injury related to alcohol use disorder.
How similar studies have performed: Previous research has shown that microRNAs play a significant role in liver disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yoon, Je-Hyun — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Yoon, Je-Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.