Investigating how insomnia and brain injuries affect treatment responses
Official title: Molecular Mechanisms Associated with Insomnia and Response to Cognitive Behavioral Therapy for Insomnia
Funded at South Texas Veterans Health Care System · NIH-10856912 · Data updated 2026-11-12
This study is looking at how insomnia affects active-duty military members who have had a traumatic brain injury, and how well a specific therapy for insomnia works for them, by checking their health before and after treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Texas Veterans Health Care System NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5IK2BX006176-02 |
| Project ID | NIH-10856912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who experience insomnia, particularly those with a history of traumatic brain injury.
✕Less likely to help
Patients without insomnia or those who do not have a history of traumatic brain injury may not benefit from this research.
What this research studies
This research explores the relationship between insomnia and traumatic brain injury (TBI), particularly focusing on how these conditions impact the effectiveness of Cognitive Behavioral Therapy for Insomnia (CBTi). It involves a cohort of active-duty personnel with insomnia, who will be categorized based on their TBI status. Participants will undergo clinical assessments and blood tests before and after a series of CBTi sessions to evaluate changes in their condition and treatment response. The goal is to understand the molecular mechanisms that may influence treatment outcomes for those with insomnia and TBI.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for insomnia in patients with traumatic brain injuries.
How similar studies have gone: Previous research has indicated that addressing sleep disturbances in patients with TBI can lead to improved outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
South Texas Veterans Health Care System
San Antonio, United States Active
Researchers
- Principal investigator: Mithani, Sara — South Texas Veterans Health Care System
- Study coordinator: Mithani, Sara
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
DESCANSO: A friendly CBT plan to ease depression, sleep problems, and fatigue in Latino cancer patients
A Spanish-speaking CBT program called DESCANSO is being tested to help Latino cancer patients feel less tired, sleep better, and happier.
-
Pimavanserin for Sleep Problems in Veterans with PTSD
This grant supports Dr. Melissa Jones to study a new medicine, pimavanserin, to help veterans with PTSD sleep better.
-
Improving WTC responder mental health with personalized sleep treatment for COMISA
Aimed at helping World Trade Center responders who have both insomnia and sleep apnea feel better by using a tailored combination of sleep therapies.
-
A new sleep-help approach for Veterans with PTSD
A new ACT-based insomnia treatment tailored for Veterans with PTSD aims to improve sleep and quality of life.
-
Cognitive Behavioral Therapy for Insomnia to Help Veterans with Psychosis
A veteran-focused CBT-I program tailored for those with psychosis aims to improve sleep and daily functioning.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.