Investigating how inflammation resolution affects heart disease
Official title: CaMK4 as a Critical Mediator of Inflammation Resolution and Trained Immunity
Funded at Vanderbilt University · NIH-10826961 · Data updated 2026-11-12
This study is looking at how a protein called CaMK4 helps reduce inflammation in heart disease, and it aims to find out how certain immune cells remember past inflammation to better understand how to improve heart health and prevent future heart problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | June 29, 2024 |
| Project end | June 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $34,295 |
| NIH project number | 1F31HL172670-01 |
| Project ID | NIH-10826961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atherosclerotic cardiovascular disease who experience recurrent cardiac events due to inflammation.
✕Less likely to help
Patients without atherosclerotic cardiovascular disease or those whose cardiac events are not related to inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called CaMK4 in resolving inflammation related to atherosclerotic cardiovascular disease (CVD). It aims to identify the mechanisms that lead to chronic inflammation in atherosclerotic plaques, which can cause recurrent cardiac events. The study will explore how macrophages, a type of immune cell, can remember past inflammatory stimuli and how this memory affects their response to inflammation. By uncovering these processes, the research seeks to develop new strategies to enhance inflammation resolution and improve heart health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and prevent recurrent heart problems in patients with atherosclerosis.
How similar studies have gone: Previous research has shown promising results in understanding inflammation resolution in cardiovascular disease, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Gonzalez, Azuah Lucrecia — Vanderbilt University
- Study coordinator: Gonzalez, Azuah Lucrecia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.