Investigating how immune responses to influenza can lead to severe bacterial infections.
The Role of Eicosanoid-PPAR axis in Exacerbating Post-Influenza Staphylococcus aureus Super-infection
This study is looking at how the immune system reacts to the flu and the risk of getting serious infections like pneumonia afterward, using mice to learn more about certain fats in the body that might help us find better treatments for people who get these infections after having the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11007248 on NIH RePORTER |
What this research studies
This research explores the immune system's response to influenza and subsequent bacterial infections, particularly focusing on how these infections can lead to severe complications like pneumonia. By studying mouse models, the researchers analyze the inflammatory responses and the role of specific lipids called eicosanoids in regulating inflammation. The goal is to understand how these lipids can either promote healing or exacerbate infections, which could lead to better treatments for patients suffering from super-infections after influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have recently recovered from influenza and are at risk of developing secondary bacterial infections.
Not a fit: Patients who have not had influenza or those with chronic bacterial infections unrelated to influenza may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients who experience severe bacterial infections following influenza.
How similar studies have performed: Previous research has shown that understanding the immune response to infections can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tam, Vincent — Temple Univ of the Commonwealth
- Study coordinator: Tam, Vincent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.