Investigating how immune responses to cytomegalovirus affect lung transplant outcomes.
Official title: Cytomegalovirus Immune Responses in Chronic Lung Allograft Dysfunction Pathogenesis
Funded at Veterans Affairs Med Ctr San Francisco · NIH-11047643 · Data updated 2026-11-12
This study is looking at how the immune system's response to cytomegalovirus (CMV) affects lung transplant patients and aims to find out which responses help protect their lungs and which ones might cause problems, so we can improve care for those who have received a lung transplant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 2I01CX002011-05A1 |
| Project ID | NIH-11047643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have undergone lung transplantation and are at risk for chronic lung allograft dysfunction.
✕Less likely to help
Patients who have not undergone lung transplantation or do not have a history of cytomegalovirus infection may not benefit from this research.
What this research studies
This research focuses on understanding the role of cytomegalovirus (CMV) immune responses in chronic lung allograft dysfunction (CLAD), which can occur after lung transplantation. The study aims to differentiate between protective and harmful immune responses to CMV using advanced technologies. By analyzing immune cell patterns and genetic signatures, the research seeks to identify how these responses influence the risk of CLAD over time. This could lead to better management strategies for lung transplant recipients.
Why it matters
Potential benefit: If successful, this research could improve lung transplant outcomes by identifying ways to manage CMV and reduce the risk of chronic lung dysfunction.
How similar studies have gone: Other research has shown promise in understanding immune responses in transplant settings, suggesting that this approach could yield valuable insights.
Where this research is happening
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Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Greenland, John — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Greenland, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.