Investigating how immune cells respond to the JC polyomavirus
NK cell responses to JC polyomavirus
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10934346
This study is looking at how certain immune cells called natural killer (NK) cells respond to a virus that can cause serious brain infections in people with weakened immune systems, with the goal of finding new treatments to help those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10934346 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the immune response of natural killer (NK) cells to the JC polyomavirus (JCPyV), particularly in individuals with weakened immune systems. The study aims to explore the adaptive capabilities of NK cells and their potential to combat JCPyV, which can lead to a severe brain infection known as progressive multifocal leukoencephalopathy (PML). By examining how these immune cells recognize and respond to JCPyV, the research seeks to develop novel immune-based therapies that could improve outcomes for affected patients. The methodology includes isolating and cloning specific NK cells that respond to JCPyV, which may lead to targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who are immunocompromised and at risk for JCPyV-related complications.
Not a fit: Patients who are not immunocompromised or do not have a history of JCPyV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of PML in immunocompromised patients.
How similar studies have performed: Previous research has shown promising results in utilizing NK cells for antiviral responses, suggesting potential success for this approach.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAN, CHEN SABRINA — UNIVERSITY OF IOWA
- Study coordinator: TAN, CHEN SABRINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Autoimmune Diseases