Investigating how immune cells in the brain respond in multiple sclerosis
Examining Microglia Reactivation in Multiple Sclerosis
['FUNDING_FELLOWSHIP'] · WASHINGTON UNIVERSITY · NIH-10995164
This study is looking at how certain brain cells called microglia behave during multiple sclerosis to find new ways to help manage the disease and improve treatment for people living with it.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10995164 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of microglia, the immune cells in the brain, in the progression of multiple sclerosis (MS). It aims to identify the specific gene signatures of these cells when they become activated during disease cycles. By examining how these microglia change in response to repeated activation, the research seeks to uncover potential therapeutic targets that could help manage or slow down MS progression. This could lead to new strategies for treating patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with relapse-remitting multiple sclerosis (RRMS) who are experiencing disease activity.
Not a fit: Patients with primary progressive multiple sclerosis (PPMS) or those who do not have a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of multiple sclerosis and improve the quality of life for patients.
How similar studies have performed: Other research has shown promise in targeting microglial activation in various neurological conditions, suggesting that this approach may yield valuable insights for multiple sclerosis as well.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARCLAY, KIA — WASHINGTON UNIVERSITY
- Study coordinator: BARCLAY, KIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, CNS Diseases, CNS disorder