Investigating how immune cells affect glioblastoma growth
AHR-mediated immunosuppression in glioblastoma
This study is looking at how certain immune cells in the brain, called tumor-associated macrophages, affect glioblastoma and how we can use this information to create new treatments that help the immune system fight the tumor better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10667431 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tumor-associated macrophages (TAMs) in glioblastoma, a common and aggressive brain tumor. Researchers are exploring how these immune cells interact with tumor cells and influence T-cell immunity, particularly through a pathway involving the aryl hydrocarbon receptor (AHR). By targeting AHR and its effects on TAMs, the study aims to develop new immunotherapeutic strategies that could enhance the immune response against glioblastoma. Patients may be involved in trials that test new treatments aimed at modifying the behavior of these immune cells to improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapies that significantly improve survival rates for glioblastoma patients.
How similar studies have performed: Previous research has shown promise in targeting immune checkpoints in cancer, suggesting that this approach could be effective for glioblastoma as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Quintana, Francisco J. — Brigham and Women's Hospital
- Study coordinator: Quintana, Francisco J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.