Investigating how immune cell receptors move and function
Official title: Endocytic dynamics and surface emergent property of leukocyte Integrins
Funded at Yale University · NIH-11228514 · Data updated 2026-11-12
This study is looking at how certain proteins help immune cells move and stick to places in the body, which could give us new insights into how these cells work in autoimmune diseases, ultimately helping patients understand their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $20,177 |
| NIH project number | 3R01GM151344-02S1 |
| Project ID | NIH-11228514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases who may benefit from advancements in understanding immune cell dynamics.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune cell dysfunction may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the behavior of leukocyte integrins, which are crucial for immune cell adhesion and migration. By exploring the sorting and dynamics of these proteins, the study aims to uncover how they contribute to cell movement and polarity, particularly in the context of autoimmune diseases. The researchers will use advanced techniques to analyze the interactions and mechanisms that govern these processes, potentially leading to new insights into immune responses. Patients may benefit from a better understanding of how immune cells function in autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by enhancing our understanding of immune cell behavior.
How similar studies have gone: Other research has shown promising results in understanding cell adhesion and migration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wu, Min — Yale University
- Study coordinator: Wu, Min
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.