Investigating how IL-23 receptor affects CD4+ T cells in skin lupus
Mechanisms of IL-23 receptor-mediated pathogenicity in CD4+ T cells
This study is looking at how a specific receptor in immune cells affects skin lupus, with the goal of finding better treatments to help people who are dealing with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10877866 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the IL-23 receptor in CD4+ T cells specifically related to cutaneous lupus erythematosus (CLE). By utilizing advanced genomic technologies, the research aims to uncover the mechanisms behind the pathogenicity of these immune cells in skin-related autoimmune conditions. The findings could lead to the development of more effective therapies for patients suffering from CLE, which significantly impacts their quality of life. The research is being conducted at Brigham and Women's Hospital in Boston, where the principal investigator has extensive experience in molecular and cellular immunology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cutaneous lupus erythematosus who are seeking better treatment options.
Not a fit: Patients with other forms of lupus or autoimmune diseases that do not involve the skin may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve the quality of life for patients with cutaneous lupus erythematosus.
How similar studies have performed: Previous research has shown promise in targeting immune pathways in autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ho, Allen Wayne — Brigham and Women's Hospital
- Study coordinator: Ho, Allen Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.