Investigating how IL-2 affects immune cell regulation and autoimmune diseases
IL-2R-dependent mechanisms in regulation of Treg homeostasis and autoimmunity
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10986979
This study is looking at how a substance called interleukin-2 (IL-2) affects a special type of immune cell that helps keep our immune system balanced, which could lead to better treatments for autoimmune diseases and fewer side effects from cancer therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10986979 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of interleukin-2 (IL-2) in regulating a specific type of immune cell known as regulatory T cells (Tregs), which are crucial for maintaining immune balance and preventing autoimmune diseases. By using advanced mouse models, the researchers are exploring how varying levels of IL-2 receptor signaling can influence Treg development and function. The findings aim to improve therapies for autoimmune conditions and reduce side effects associated with cancer immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases or those undergoing cancer immunotherapy.
Not a fit: Patients with conditions unrelated to autoimmune diseases or those not receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for autoimmune diseases and safer cancer therapies.
How similar studies have performed: Previous research has shown promising results in using low-dose IL-2 for Treg-targeted therapies, indicating potential success for this approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MALEK, THOMAS R — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: MALEK, THOMAS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy, anticancer immunotherapy, Autoimmune Diseases, autoimmune disorder