Investigating how IgG4 antibodies function in autoimmune diseases
Examining IgG4 sialylation as a gain of function post-translation modification in IgG4-related diseases
This study is looking at how certain changes in IgG4 antibodies might affect people with IgG4-related diseases, and it involves testing blood samples from both patients and healthy individuals to learn more about these antibodies and how they could help in treating the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10865053 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of IgG4 antibodies in IgG4-related diseases, which are characterized by inflammation and tissue damage. The team will analyze blood samples from patients with these diseases and healthy individuals to explore how specific modifications to IgG4 antibodies affect their function. By examining the binding and activity of these antibodies in laboratory tests, the researchers aim to uncover new insights into their role in disease pathology and potential therapeutic applications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with IgG4-related diseases.
Not a fit: Patients with conditions unrelated to IgG4-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative antibody-based therapies for patients suffering from IgG4-related diseases.
How similar studies have performed: Other research has shown promise in understanding antibody modifications in autoimmune diseases, suggesting potential for success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Anthony, Robert Mccullough — Massachusetts General Hospital
- Study coordinator: Anthony, Robert Mccullough
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.