Investigating how hydrogen peroxide affects blood vessel function
Hydrogen peroxide in endothelial function and dysfunction
This study is looking at how a substance called hydrogen peroxide affects blood vessel function and may contribute to high blood pressure, helping us understand more about the causes of heart and blood vessel problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10761698 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of reactive oxygen species, particularly hydrogen peroxide, in regulating nitric oxide signaling within blood vessels. Using advanced biosensors and chemogenetic techniques, the study aims to uncover the molecular mechanisms that lead to endothelial dysfunction and hypertension. By analyzing how different levels of hydrogen peroxide influence blood vessel responses, the research seeks to clarify the transition from normal to pathological conditions. This could provide insights into the underlying causes of various vascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from vascular diseases or hypertension.
Not a fit: Patients with non-vascular related conditions or those not experiencing hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for vascular diseases and hypertension by targeting the molecular pathways involved.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress and vascular function, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Michel, Thomas — Brigham and Women's Hospital
- Study coordinator: Michel, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.