Investigating how HIV affects diabetes complications in low-income countries
Official title: Understanding the Mechanism of HIV Associated with Diabetic Complications in Low- and Middle-Income Country
Funded at Ohio State University · NIH-10999211 · Data updated 2026-11-12
This study is looking at how HIV and its treatments might lead to diabetes problems by affecting certain immune cells that can harm the pancreas, and it aims to find ways to help young adults living with HIV avoid diabetes, especially in low- and middle-income countries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $233,453 |
| NIH project number | 1R21TW012876-01 |
| Project ID | NIH-10999211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young adults living with HIV, particularly those in low- and middle-income countries like Sri Lanka.
✕Less likely to help
Patients who are not living with HIV or those who do not have a risk of developing diabetes may not benefit from this research.
What this research studies
This research aims to understand how HIV and its treatments may lead to diabetes complications by affecting the immune system, particularly natural killer (NK) cells, which can damage the pancreas. The study will explore the role of endoplasmic reticulum (ER) stress induced by HIV and antiretroviral therapy, making pancreatic tissue more vulnerable to immune attacks. By analyzing the immune profiles of people living with HIV, the research seeks to identify potential interventions that could prevent diabetes in this population. The findings could provide insights into managing diabetes risks among young adults living with HIV in low- and middle-income countries.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing diabetes in people living with HIV, improving their overall health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms linking HIV and diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Liyanage, Namal — Ohio State University
- Study coordinator: Liyanage, Namal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.