Investigating how HIV-1 affects immune activation and aging in treated patients
Official title: Nucleic acid-containing immune complexes and immune activation
Funded at University of California-Irvine · NIH-10924429 · Data updated 2026-11-12
This study is looking at how HIV-1 keeps causing inflammation and immune system issues in people who are taking medication to manage the virus, and it hopes to find ways to help improve health for those living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $211,950 |
| NIH project number | 1R21AI184196-01 |
| Project ID | NIH-10924429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on anti-retroviral therapy and have well-controlled viral loads.
✕Less likely to help
Patients who are not living with HIV or those who are not on anti-retroviral therapy may not benefit from this research.
What this research studies
This research aims to understand how HIV-1 continues to cause immune activation and inflammation in individuals who are on anti-retroviral therapy (ART). It focuses on the role of immune complexes formed by HIV components and antibodies in stimulating immune cells called monocytes. By examining these interactions, the study seeks to uncover the mechanisms behind chronic inflammation and accelerated aging in people living with HIV. The findings could lead to better management strategies for improving health outcomes in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce inflammation and enhance the longevity and quality of life for people living with HIV.
How similar studies have gone: Previous research has indicated that understanding immune activation in HIV-infected individuals can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Forthal, Donald N — University of California-Irvine
- Study coordinator: Forthal, Donald N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.