Investigating how gut bacteria affect inflammation in lupus patients
Official title: Thromboinflammatory pathways triggered by gut dysbiosis in patients with Lupus
Funded at New York University School of Medicine · NIH-10991804 · Data updated 2026-11-12
This study is looking at how changes in gut bacteria might make lupus, especially lupus nephritis, worse, and it's for people with lupus who want to understand how their gut health could affect their condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $205,519 |
| NIH project number | 5R21AI180737-02 |
| Project ID | NIH-10991804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Systemic Lupus Erythematosus, especially those experiencing Lupus Nephritis.
✕Less likely to help
Patients with lupus who do not have significant gut microbiome imbalances or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research explores the connection between gut microbiome imbalances and the worsening of Systemic Lupus Erythematosus (SLE), particularly in patients experiencing Lupus Nephritis. By analyzing blood samples from patients during periods of high disease activity, the study aims to identify how specific gut bacteria may trigger inflammatory responses and platelet activation. The research employs advanced RNA sequencing techniques to uncover the mechanisms behind these interactions, potentially leading to new insights into lupus management.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target gut microbiome imbalances to improve outcomes for lupus patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Silverman, Gregg Joshua — New York University School of Medicine
- Study coordinator: Silverman, Gregg Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.