Investigating how glycine can help treat atherosclerosis
Mechanisms of glycine-based therapy for atherosclerosis
This study is looking at how glycine, a natural amino acid, might help manage atherosclerosis and lower the risk of heart disease, especially for people dealing with conditions like type 2 diabetes and obesity, by seeing how it affects cholesterol and fat in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-10649691 on NIH RePORTER |
What this research studies
This research explores the role of glycine, an amino acid, in managing atherosclerosis, a major cause of cardiovascular disease. It examines how glycine affects cholesterol metabolism and its potential protective effects against conditions like type 2 diabetes and obesity. The study involves using specially modified diets to assess the impact of glycine on lipid accumulation and other cardiovascular risk factors in both human and mouse models. By understanding these mechanisms, the research aims to identify new therapeutic strategies for reducing cardiovascular disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular disease, particularly those with conditions like type 2 diabetes, obesity, or high cholesterol.
Not a fit: Patients who do not have cardiovascular risk factors or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly lower the risk of cardiovascular disease by targeting multiple metabolic pathways.
How similar studies have performed: Previous research has shown promising results with glycine in related metabolic conditions, suggesting potential for success in this novel application.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Rom, Oren Shalom — Louisiana State Univ Hsc Shreveport
- Study coordinator: Rom, Oren Shalom
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.