Investigating how glutamate affects cognitive control in adolescents exposed to trauma
The Role for in vivo Glutamate Modulation in Maintaining Cognitive Control in Trauma-Exposed Adolescents
['FUNDING_FELLOWSHIP'] · WAYNE STATE UNIVERSITY · NIH-10871700
This study is looking at how childhood trauma affects the way teenagers think and respond to challenges, especially when they feel threatened, and it aims to find out how changes in brain chemistry might help us develop better treatments for anxiety in young people.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10871700 on ClinicalTrials.gov |
What this research studies
This research explores the impact of childhood trauma on cognitive control in adolescents, particularly focusing on how emotional responses to threats can disrupt cognitive abilities. By utilizing advanced imaging techniques, specifically in vivo ¹H functional MR spectroscopy, the study aims to measure changes in glutamate levels in the brain during cognitive tasks. The goal is to better understand the biochemical mechanisms that underlie cognitive engagement in trauma-exposed youth, which could lead to improved therapeutic strategies for anxiety disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who have experienced childhood trauma and exhibit symptoms of anxiety disorders.
Not a fit: Patients who have not experienced trauma or do not have anxiety disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive control in adolescents suffering from anxiety due to trauma.
How similar studies have performed: While the use of in vivo ¹H fMRS is a relatively novel approach, previous studies have shown promise in understanding cognitive processes through advanced imaging techniques.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCE, JOHN — WAYNE STATE UNIVERSITY
- Study coordinator: FRANCE, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anxiety Disorders