Investigating how glioblastoma cells adapt to stress from RAS signaling.
EGFR signaling network adaptations to overcome RAS-induced membrane stress in glioblastoma
This study is looking at how certain changes in a protein called EGFR help glioblastoma brain cancer cells survive tough conditions, and by understanding these processes better, researchers hope to find new ways to treat patients with this challenging cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10903899 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a type of brain cancer, particularly how certain mutations in the EGFR protein help cancer cells survive under stress caused by RAS signaling. The study aims to understand the mechanisms behind these adaptations by building a computational model that simulates the interactions between proteins involved in this process. By analyzing these interactions, researchers hope to uncover new insights into how glioblastoma cells manage to thrive despite the challenges posed by their environment. This could lead to better-targeted therapies for patients with this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those with mutations in the EGFR gene.
Not a fit: Patients with other types of brain tumors or those without EGFR mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for patients with glioblastoma.
How similar studies have performed: Other research has shown promising results in understanding cancer cell adaptations, making this approach both relevant and potentially impactful.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Lazzara, Matthew J — University of Virginia
- Study coordinator: Lazzara, Matthew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.