Investigating how glial cells develop and function in the brain using zebrafish
Genetic and cellular analysis of glial development and function in vertebrates
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11056173
This study is looking at special brain cells called glial cells in zebrafish to learn how they help protect the brain and respond to injuries, which could lead to better treatments for brain disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11056173 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the development and function of glial cells, specifically oligodendrocytes and microglia, in the central nervous system. By utilizing zebrafish as a model organism, the researchers aim to identify new genes that play crucial roles in myelination and the immune response of the brain. The study employs genetic and cellular techniques to explore how these glial cells contribute to brain health and respond to injury. Insights gained from this research could help in understanding brain disorders and developing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve glial cell dysfunction or damage.
Not a fit: Patients with conditions unrelated to glial cell function or those who do not have neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain diseases by enhancing our understanding of glial cell functions and their role in neural repair.
How similar studies have performed: Previous research has shown promising results in understanding glial cell functions using zebrafish models, indicating that this approach is both valid and potentially impactful.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TALBOT, WILLIAM S — STANFORD UNIVERSITY
- Study coordinator: TALBOT, WILLIAM S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: axon injury, axonal injury, Brain Diseases, Brain Disorders