Investigating how genetic variations affect antibody therapies in Type 1 Diabetes
Official title: Fcy Receptor-Mediated Pharmacogenomics of Antibody Therapies in Type 1 Diabetes
Funded at University of Florida · NIH-10949606 · Data updated 2026-11-12
This study is looking at how your genes might affect how well antibody treatments work for people who have just been diagnosed with Type 1 Diabetes, to help find out who might benefit the most from these therapies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $90,000 |
| NIH project number | 1K99DK140511-01 |
| Project ID | NIH-10949606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals recently diagnosed with Type 1 Diabetes who are considering antibody therapy.
✕Less likely to help
Patients with long-standing Type 1 Diabetes or those not eligible for antibody therapies may not benefit from this research.
What this research studies
This research focuses on understanding how genetic differences in Fc gamma receptors (FcγR) may influence the effectiveness of antibody therapies for individuals recently diagnosed with Type 1 Diabetes (T1D). By examining these genetic variants, the study aims to determine if they affect the body's response to treatments that target immune cells responsible for the destruction of insulin-producing pancreatic β-cells. The approach involves analyzing patient samples and correlating genetic data with treatment outcomes to identify potential predictors of therapy success.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective antibody therapies for patients with Type 1 Diabetes.
How similar studies have gone: Previous research has shown that genetic variations can significantly impact the effectiveness of antibody therapies in other autoimmune diseases, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Shapiro, Melanie R — University of Florida
- Study coordinator: Shapiro, Melanie R
Related research
Other NIH-funded projects on the same topics.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
-
Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.