Investigating how genetic variants affect immune responses in Type 1 diabetes
Official title: Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
Funded at University of Kansas Medical Center · NIH-10903049 · Data updated 2026-11-12
This study is looking at how certain genes might affect the immune system and insulin-producing cells in people with Type 1 diabetes, especially in relation to viral infections, and it invites patients to help by sharing samples or information to better understand these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,192,518 |
| NIH project number | 7R01DK127497-04 |
| Project ID | NIH-10903049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a genetic predisposition to Type 1 diabetes, particularly those with known variants in the IFIH1 gene.
✕Less likely to help
Patients without a genetic predisposition to Type 1 diabetes or those who do not have the specific IFIH1 variants may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variants in the IFIH1 gene influence the immune response and beta-cell function in individuals with Type 1 diabetes (T1D). It examines the role of viral infections, particularly Coxsackievirus B, in triggering T1D and how these genetic variants may lead to an exaggerated immune response. By studying immune cells and beta-cells in the context of viral infection, the research aims to uncover the mechanisms that contribute to the onset of autoimmunity in T1D. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the prevention and treatment of Type 1 diabetes by targeting the immune response.
How similar studies have gone: Previous research has shown that understanding genetic factors and their interaction with viral infections can provide valuable insights into autoimmune diseases, suggesting potential for success in this area.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Tse, Hubert M — University of Kansas Medical Center
- Study coordinator: Tse, Hubert M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.