Investigating how genetic changes in IL-17 signaling affect autoimmune diabetes
Official title: IL17 Signaling in Monogenic Type 1 Diabetes
Funded at University of California, San Francisco · NIH-11120774 · Data updated 2026-11-12
This study is looking at how certain genetic changes might affect the immune system and lead to autoimmune diabetes, and it's for families who have a history of this condition to help us learn more about what causes it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 25, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $287,000 |
| NIH project number | 1R21AI191139-01 |
| Project ID | NIH-11120774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with monogenic forms of autoimmune diabetes or those with a family history of the condition.
✕Less likely to help
Patients with type 1 diabetes not linked to genetic mutations affecting IL-17 signaling may not benefit from this research.
What this research studies
This research aims to explore the role of genetic mutations that impact IL-17 signaling in the development of autoimmune diabetes. By studying individuals and families with suspected monogenic forms of this condition, the research seeks to uncover new biological pathways that contribute to the disease. Advanced genetic sequencing techniques will be employed to identify rare mutations linked to type 1 diabetes, particularly focusing on families with a history of the condition. The findings could enhance our understanding of immune tolerance and the mechanisms leading to pancreatic beta-cell failure.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of autoimmune diabetes and potentially inform targeted therapies.
How similar studies have gone: Previous research has successfully identified genetic mutations linked to autoimmune diabetes, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: German, Michael S — University of California, San Francisco
- Study coordinator: German, Michael S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.