Investigating how ferritin light chain affects kidney injury during sepsis
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury
This study is looking at how a protein called ferritin light chain might help protect the kidneys from damage during sepsis, which could lead to new treatments for people facing this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11018536 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of ferritin light chain (FtL) in preventing kidney injury associated with sepsis. It examines how FtL can reduce inflammation and damage in kidney cells by inhibiting certain signaling pathways that lead to acute kidney injury. The study utilizes animal models to explore the effects of FtL on inflammatory responses and kidney function during sepsis, aiming to identify potential therapeutic strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are experiencing acute kidney injury due to sepsis.
Not a fit: Patients with chronic kidney disease or those not experiencing sepsis-related kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect kidney function in patients with sepsis-related injuries.
How similar studies have performed: Other research has shown promising results in using similar approaches to mitigate inflammation and protect kidney function, suggesting potential for success in this study.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Bolisetty, Subhashini — University of Alabama at Birmingham
- Study coordinator: Bolisetty, Subhashini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.