Investigating how fatty acid metabolism affects skin inflammation and immune responses
Official title: Metabolomics and transcriptomics analyses of cell-specific regulation of fatty acid synthesis and metabolic reprogramming in skin inflammation
Funded at Molecular Medicine Research Institute · NIH-11118988 · Data updated 2026-11-12
This study is looking at how the way our bodies process fats affects immune cells that cause skin inflammation, with the hope of finding new treatments for skin conditions like psoriasis that could help patients feel better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Molecular Medicine Research Institute NIH-funded |
| Lab location | 1 site (Sunnyvale, United States) |
| Project start | June 17, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $97,500 |
| NIH project number | 5R03AI185412-02 |
| Project ID | NIH-11118988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory skin conditions such as psoriasis or other autoimmune disorders.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by autoimmune diseases may not receive any benefit from this research.
What this research studies
This research focuses on understanding how the metabolism of fatty acids influences the activation of immune cells involved in skin inflammation. By analyzing specific cell types, the study aims to uncover the mechanisms by which fatty acid synthesis can lead to either pro-inflammatory or anti-inflammatory responses. The researchers will utilize advanced techniques in metabolomics and transcriptomics to explore these processes, potentially identifying new therapeutic strategies for inflammatory skin conditions. Patients may benefit from insights that could lead to targeted treatments for conditions like psoriasis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage or treat inflammatory skin diseases.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways for treating inflammatory diseases, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
Molecular Medicine Research Institute
Sunnyvale, United States Active
Researchers
- Principal investigator: Kang, Young Jun — Molecular Medicine Research Institute
- Study coordinator: Kang, Young Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.