Investigating how fatty acid metabolism affects blood vessel health in peripheral artery disease
Lipidation and Vascular Disease
This study is looking at how a specific enzyme affects blood vessel health in people with peripheral artery disease (PAD), which is becoming more common as we age or if we have diabetes, to find new ways to help improve treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10812480 on NIH RePORTER |
What this research studies
This research focuses on understanding peripheral artery disease (PAD), a condition that affects blood flow and is becoming more common due to aging and diabetes. The study examines how fatty acid metabolism, particularly the process of protein lipidation, influences the health of blood vessels. Using a mouse model that mimics human PAD, researchers will explore the role of a specific enzyme, APT1, in regulating blood vessel function and how its deficiency leads to vascular issues. The findings aim to uncover new therapeutic targets for improving treatment options for patients with PAD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with peripheral artery disease, particularly those who are older or have diabetes.
Not a fit: Patients without peripheral artery disease or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce complications for patients suffering from peripheral artery disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of fatty acid metabolism in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Semenkovich, Clay F. — Washington University
- Study coordinator: Semenkovich, Clay F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.