Investigating how environmental toxins and genetic factors affect Parkinson's disease
Toxicant-induced neurotoxicity mediated by glia-neuron and gene-environment interactions in Parkinson's disease
This study is looking at how certain harmful substances in the environment and genetic changes might lead to Parkinson's disease, and it’s exploring ways to protect brain cells and find new treatments that could help people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11085059 on NIH RePORTER |
What this research studies
This research focuses on understanding how environmental toxicants and genetic mutations contribute to the development of Parkinson's disease (PD). It examines the interactions between glial cells and dopamine neurons, and how these interactions may increase the vulnerability of neurons to damage. The study also explores whether targeting mitochondrial dynamics can provide new therapeutic options for PD. By using advanced experimental models, the research aims to uncover mechanisms that could lead to effective treatments for this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease, particularly those with known genetic mutations or significant exposure to environmental toxins.
Not a fit: Patients with Parkinson's disease who do not have genetic mutations or environmental exposure may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that modify the progression of Parkinson's disease and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of environmental factors and genetic interactions in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Tieu, Kim — Florida International University
- Study coordinator: Tieu, Kim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.