Investigating how environmental factors and cell division timing affect brain development
Official title: Neural Progenitor Environmental Sense, Mitotic Time, and Mitotic Location and their Effects on Corticogenesis
Funded at Johns Hopkins University · NIH-11001618 · Data updated 2026-11-12
This study is looking at how different factors, like when and where brain cells divide, can affect brain development and may contribute to conditions like autism and bipolar disorder, using special mouse models to help understand these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 12, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,974 |
| NIH project number | 1F99NS139554-01 |
| Project ID | NIH-11001618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by autism spectrum disorder, bipolar disorder, or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to the mechanisms being studied may not benefit from this research.
What this research studies
This research explores the impact of environmental cues and the timing and location of cell division on brain development, particularly in relation to conditions like autism spectrum disorder and bipolar disorder. By using mutant mouse models, the study examines how delays in cell division and changes in where cells divide can lead to improper brain organization and function. The research aims to uncover the mechanisms behind neurodevelopmental disorders by focusing on the role of specific genes and cellular processes involved in brain cell production.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurodevelopmental disorders and potential therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding neurodevelopmental disorders through similar genetic and cellular approaches.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Nicholas, Zachary Bryant — Johns Hopkins University
- Study coordinator: Nicholas, Zachary Bryant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.