Investigating how diet and gut bacteria influence type 1 diabetes risk
AhR activation and susceptibility to type 1 diabetes
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10454811
This study is looking at how things like what we eat and our gut bacteria might affect the chances of getting type 1 diabetes, focusing on a special protein that helps our immune system, to find new ways to prevent this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10454811 on ClinicalTrials.gov |
What this research studies
This research explores the connection between environmental factors, such as diet and gut microbiome, and the risk of developing type 1 diabetes (T1D). It focuses on the role of the aryl hydrocarbon receptor (AhR), a protein that responds to various environmental signals, in influencing immune cell behavior related to T1D. By studying non-obese diabetic mice, the research aims to understand how different levels of AhR activation can lead to either the promotion or prevention of T1D. This could help identify new strategies for preventing this autoimmune disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for type 1 diabetes, including those with a family history of the disease or other autoimmune conditions.
Not a fit: Patients who already have established type 1 diabetes may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for type 1 diabetes, potentially reducing its incidence.
How similar studies have performed: Previous research has shown promising results in understanding the role of environmental factors in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EHRLICH, ALLISON — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: EHRLICH, ALLISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases