Investigating how diabetes affects kidney injury and growth
Official title: Tubular Hypertrophy and AKI Susceptibility in Diabetes
Funded at Augusta University · NIH-11108924 · Data updated 2026-11-12
This study is looking at how kidney problems in people with diabetes happen and what makes them worse, so we can find better ways to keep their kidneys healthy, and we might ask some patients to help by sharing samples or information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $596,345 |
| NIH project number | 1R01DK143226-01 |
| Project ID | NIH-11108924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are diabetic patients who are at risk of acute kidney injury.
✕Less likely to help
Patients without diabetes or those who do not have any kidney-related issues may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind acute kidney injury (AKI) in diabetic patients, who are at a higher risk for severe kidney complications. The study will explore how renal hypertrophy, or the enlargement of kidney cells, contributes to AKI susceptibility and severity in diabetes. By examining specific molecular pathways and cellular processes, such as autophagy and endoplasmic reticulum stress, the research aims to identify potential targets for improving kidney health in diabetic individuals. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of kidney injury and improve outcomes for diabetic patients.
How similar studies have gone: Previous research has shown promising results in understanding kidney injury mechanisms in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Chen, Jian-Kang — Augusta University
- Study coordinator: Chen, Jian-Kang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.