Investigating how CXCL12 signaling affects lung blood vessel development and disease.
Official title: CXCL12 signaling axis in pulmonary arterial heterogeneity, development, and disease
Funded at Children's Hosp of Philadelphia · NIH-10905162 · Data updated 2026-11-12
This study is looking at how a specific signaling process affects the growth of blood vessels in the lungs, which could help us understand and find new treatments for lung diseases like pulmonary hypertension, so patients can learn more about their conditions and possible new options for care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $657,308 |
| NIH project number | 1R56HL167937-01 |
| Project ID | NIH-10905162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with pulmonary vascular diseases or those at risk for conditions like pulmonary hypertension.
✕Less likely to help
Patients with non-pulmonary related vascular issues or those without any lung disease may not benefit from this research.
What this research studies
This research explores the role of CXCL12 signaling in the development and function of blood vessels in the lungs. By examining how this signaling pathway influences the growth and differentiation of arterial endothelial cells, the study aims to uncover mechanisms that could lead to lung diseases such as pulmonary hypertension. The researchers will utilize advanced techniques like single-cell RNA sequencing to analyze the cellular diversity within the pulmonary endothelium, which may reveal new therapeutic targets for treating lung conditions. Patients may benefit from insights gained about the underlying causes of their diseases and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for lung diseases that currently have limited treatment options.
How similar studies have gone: Other research has shown promising results in understanding vascular development and disease through similar cellular signaling pathways, indicating potential for success in this area.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Frank, David Brian — Children's Hosp of Philadelphia
- Study coordinator: Frank, David Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.