Investigating how COVID-19 affects brain pathology related to dementia

Who could benefit from this research

What this research studies

This research explores the connections between COVID-19 and the progression of Lewy body pathology and dementia. It examines how the virus may trigger changes in the brain that lead to neurodegenerative disorders, particularly focusing on the interactions between viral proteins and α-synuclein, a protein associated with dementia. The study utilizes a human ACE2 transgenic mouse model to investigate these mechanisms in a controlled environment, aiming to understand the underlying biological processes that may contribute to cognitive decline in patients post-COVID-19.

Why it matters

Where this research is happening

• Louisiana State Univ Hsc Shreveport
  Shreveport, United States Active

Researchers

• Principal investigator: Lu, Xiaohong — Louisiana State Univ Hsc Shreveport
• Study coordinator: Lu, Xiaohong

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.