Investigating how corticosteroids affect memory and brain structure.
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
This study is looking at how long-term use of corticosteroid medications might affect memory and brain health in people who take them for different health issues, so we can better understand any changes in thinking and mood that might happen over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10556437 on NIH RePORTER |
What this research studies
This research explores the impact of chronic corticosteroid exposure on the human hippocampus, which is crucial for memory. By using neurocognitive testing and high-resolution brain imaging, the study aims to understand how these medications may alter memory performance and brain structure. Patients receiving corticosteroids for various conditions will be evaluated to see how these drugs affect their cognitive functions and brain health over time. The findings could provide insights into the relationship between corticosteroid use, memory decline, and mood disorders.
Who could benefit from this research
Good fit: Ideal candidates include individuals who are currently prescribed corticosteroids for conditions such as rheumatic diseases or chronic pain.
Not a fit: Patients not using corticosteroids or those with no cognitive concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients using corticosteroids, potentially mitigating memory-related side effects.
How similar studies have performed: Previous research has indicated cognitive impairments associated with corticosteroid use, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Brown, E Sherwood — Ut Southwestern Medical Center
- Study coordinator: Brown, E Sherwood
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.