Investigating how CMV infection may trigger type 1 diabetes in at-risk children
CMV responses in autoantibody positive subjects advocate antiviral treatments for prevention of T1D
This study is looking at how a virus called cytomegalovirus (CMV) might play a part in the development of type 1 diabetes in kids, by tracking their immune responses over time to see how it all connects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10689063 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cytomegalovirus (CMV) infection in the development of type 1 diabetes (T1D) in children. By conducting prospective longitudinal testing, researchers aim to identify environmental factors that contribute to T1D before clinical symptoms appear. The study examines the immune response, particularly the behavior of CD8 T cells, in children who are at risk for T1D and have been exposed to CMV. The goal is to uncover the connections between viral infections and autoimmune responses that lead to T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk for developing type 1 diabetes and have been exposed to CMV.
Not a fit: Patients who are not at risk for type 1 diabetes or have not been exposed to CMV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for type 1 diabetes in children at risk due to viral infections.
How similar studies have performed: Previous research has indicated a link between viral infections and autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Sarvetnick, Nora E — University of Nebraska Medical Center
- Study coordinator: Sarvetnick, Nora E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.