Investigating how cilia and melanin-concentrating hormone receptors affect Alzheimer's disease
The role of ciliary melanin-concentrating hormone receptors in Alzheimer's disease
This study is looking at how tiny structures in our cells, called primary cilia, and certain receptors might affect memory problems in Alzheimer's disease, using mice to see if targeting these areas can help improve their thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chapman University NIH-funded |
| Lab location | 1 site (Orange, United States) |
| Project ID | NIH-10711269 on NIH RePORTER |
What this research studies
This research explores the role of primary cilia and melanin-concentrating hormone receptors in Alzheimer's disease. By examining mouse models of Alzheimer's, the study aims to understand how changes in cilia structure and function may influence cognitive deficits associated with the disease. The researchers will investigate whether targeting these receptors can improve memory and cognitive function in affected mice. This approach combines expertise from two laboratories to provide a comprehensive analysis of the relationship between cilia and Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early to late-stage Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognitive function in Alzheimer's patients.
How similar studies have performed: While the investigation of cilia in Alzheimer's is relatively novel, similar approaches in other neurological disorders have shown promise.
Where this research is happening
Orange, United States
- Chapman University — Orange, United States (Active)
Researchers
- Principal investigator: Nauli, Surya — Chapman University
- Study coordinator: Nauli, Surya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.