Investigating how changes in the MAPK pathway affect thyroid cancer development
MAPK pathway modulation in thyroid tumorigenesis
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10771325
This study is looking at how certain changes in a specific cell signaling pathway can affect thyroid cancer growth and behavior, using mouse models to help find better treatments for people with thyroid cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10771325 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the MAPK signaling pathway in thyroid cancer, particularly how different mutations within this pathway can lead to various tumor behaviors and microenvironments. By using mouse models of thyroid cancer, the study aims to explore the effects of specific oncogenes, such as Hras and Braf, on tumor growth and the surrounding tissue. The goal is to uncover the mechanisms that drive tumor progression and metastasis, which could lead to more effective treatments for patients with thyroid cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with thyroid cancer, particularly those with follicular or papillary types.
Not a fit: Patients with thyroid cancer types not related to the MAPK pathway or those without a diagnosis of thyroid cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for thyroid cancer by identifying specific pathways that contribute to tumor growth and spread.
How similar studies have performed: Previous research has shown that targeting specific pathways in cancer can lead to significant advancements in treatment, suggesting that this approach may also yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCO, AIME T. — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: FRANCO, AIME T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Thyroid Cancer