Investigating how changes in proteins may trigger autoimmune responses in Type 1 diabetes.
Official title: Posttranslational Neoantigens in Autoimmunity and Metabolism in T1D
Funded at Yale University · NIH-10991026 · Data updated 2026-11-12
This study is looking at how certain changes in proteins might help us spot Type 1 diabetes early, which could lead to better ways to diagnose and treat the condition for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 25, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $730,784 |
| NIH project number | 5R01DK135052-03 |
| Project ID | NIH-10991026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 diabetes or those at risk of developing the condition.
✕Less likely to help
Patients with Type 2 diabetes or other non-autoimmune related metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding how specific changes to proteins in the body, known as posttranslational modifications (PTMs), can serve as early indicators of Type 1 diabetes. By analyzing these modifications, the study aims to uncover how they may lead to autoimmune responses that damage pancreatic beta cells, which are crucial for insulin production. The research employs advanced techniques like MultiOrdinate Spectral Analysis (MIMOSA) to assess metabolic changes and their impact on glucose sensing and insulin secretion. Patients may benefit from insights that could lead to new diagnostic tools or treatments for Type 1 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and improved treatment strategies for Type 1 diabetes.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Mamula, Mark J — Yale University
- Study coordinator: Mamula, Mark J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.