Investigating how changes in gut bacteria affect immune outcomes in children receiving stem cell transplants.
Understanding longitudinal microbiome change in relation to immunologic outcomes in pediatric SCT recipients.
This study is looking at how the bacteria in the gut of children who receive stem cell transplants change and how these changes might affect their recovery and any complications, like GVHD, to help find ways to make their healing process better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11001199 on NIH RePORTER |
What this research studies
This research focuses on understanding how the gut microbiome changes in children undergoing stem cell transplants and how these changes relate to immune system recovery and complications like acute graft-versus-host disease (GVHD). By analyzing data from pediatric patients, the study aims to identify specific microbiome features that could predict adverse outcomes and explore how medications may impact these changes. The goal is to develop strategies that could help prevent complications and improve recovery for these young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are receiving stem cell transplants.
Not a fit: Patients who are not undergoing stem cell transplants or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for predicting and preventing serious complications in children undergoing stem cell transplants.
How similar studies have performed: Other research has shown promising results in understanding the microbiome's role in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Elgarten, Caitlin Walfoort — Children's Hosp of Philadelphia
- Study coordinator: Elgarten, Caitlin Walfoort
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.