Investigating how changes in cellular redox state influence brain development and behavior.
Official title: Determining how redox changes affect optic tectum circuitry development and behavior.
Funded at Brigham Young University · NIH-10874295 · Data updated 2026-11-12
This study is looking at how changes in cell chemistry can impact brain development and behavior, especially in a part of the brain that helps us process what we see, using zebrafish embryos to see how certain drugs might affect this process and lead to conditions like autism, with the hope of finding better treatments for those who need them.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $454,500 |
| NIH project number | 1R15NS131998-01A1 |
| Project ID | NIH-10874295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years, particularly those with neurodevelopmental concerns or a family history of such disorders.
✕Less likely to help
Patients who are older than 11 years or do not have any neurodevelopmental disorders may not benefit from this research.
What this research studies
This research focuses on understanding how the redox state of cells affects the development of brain circuitry and behavior, particularly in the superior colliculus, a brain region involved in processing sensory information. The study uses zebrafish embryos to explore how exposure to certain drugs, like valproic acid, can disrupt normal neuronal development and potentially lead to neurodevelopmental disorders such as autism. By examining these cellular processes, the research aims to uncover mechanisms that could inform future treatments for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurodevelopmental disorders and potential therapeutic strategies for improving brain function in affected children.
How similar studies have gone: Previous research has shown promising results in understanding the role of redox states in neuronal development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Suli, Arminda — Brigham Young University
- Study coordinator: Suli, Arminda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.