Investigating how changes in a specific signaling pathway affect thyroid cancer development
MAPK pathway modulation in thyroid tumorigenesis
This study is looking at how certain changes in a specific pathway in the body might affect the growth of thyroid cancer, with the hope of finding better ways to treat patients who have this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10570925 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the MAPK signaling pathway in thyroid cancer, which is the most common endocrine malignancy. By using mouse models, the study will explore how different mutations in this pathway influence tumor growth and the surrounding tumor environment. The goal is to uncover why certain mutations lead to more aggressive forms of cancer and how they affect the recruitment of supportive cells and structures around the tumor. This could provide insights into better treatment strategies for patients with thyroid cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with thyroid cancer, particularly those with follicular or papillary types.
Not a fit: Patients with benign thyroid conditions or those without any thyroid-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with thyroid cancer.
How similar studies have performed: Previous research has shown promising results in understanding cancer pathways, making this approach both relevant and potentially impactful.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Franco, Aime T. — Children's Hosp of Philadelphia
- Study coordinator: Franco, Aime T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.