Investigating how certain receptors affect immune responses in autoimmune hepatitis
Alterations of aryl hydrocarbon receptor signaling in autoimmune hepatitis
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10463827
This study is looking at how a specific part of the immune system affects autoimmune hepatitis, a liver disease, to find new ways to help improve treatment for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10463827 on ClinicalTrials.gov |
What this research studies
This research focuses on autoimmune hepatitis, a serious liver disease that can lead to severe complications. It examines the role of the aryl hydrocarbon receptor (AhR) in regulating immune responses, particularly how it influences specific immune cells involved in the disease. By understanding these mechanisms, the research aims to identify potential new therapeutic targets that could improve treatment outcomes for patients with autoimmune hepatitis. The study involves analyzing immune cell behavior and receptor interactions in patients with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune hepatitis who may not respond well to current treatments.
Not a fit: Patients with autoimmune hepatitis who are already effectively managed with existing therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage autoimmune hepatitis and improve patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting immune receptors for autoimmune diseases, suggesting that this approach could yield beneficial results.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONGHI, MARIA SERENA — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: LONGHI, MARIA SERENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder