Investigating how certain proteins are modified by a molecule called glutathione in cancer and cell movement.
Chemical Proteomic Strategy to Investigate Cysteine Glutathionylation
This study is looking at how certain molecules in our cells can change proteins in ways that might affect how cancer cells move and grow, and it's designed for researchers who want to understand these processes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10915670 on NIH RePORTER |
What this research studies
This research focuses on understanding how reactive oxygen species, like hydrogen peroxide, affect protein modifications known as S-glutathionylation, which can influence cell migration and cancer progression. By using a novel chemical proteomic approach, the researchers aim to identify specific cysteine residues in proteins that are sensitive to glutathionylation during cell migration. This involves studying mammalian cell lines and employing advanced quantitative proteomics and bioinformatics to analyze the data. The goal is to uncover the mechanisms by which these modifications regulate important biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cancers who may benefit from improved understanding of cancer cell behavior and treatment strategies.
Not a fit: Patients with early-stage cancers or non-cancerous conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and potential therapeutic targets for advanced cancers.
How similar studies have performed: Previous research has shown promise in understanding protein modifications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ahn, Young-Hoon — Drexel University
- Study coordinator: Ahn, Young-Hoon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.