Investigating how certain molecules affect nerve cell and astrocyte development
Converging molecular mechanisms in axon degeneration and astrocyte morphogenesis
This study is looking at how certain molecules affect brain cells called astrocytes and their connection to nerve cell damage, using zebrafish to help us learn more about brain health and potentially improve our understanding of conditions that cause nerve degeneration.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10947696 on NIH RePORTER |
What this research studies
This research explores the roles of specific molecules in the development of astrocytes, a type of brain cell, and their relationship with nerve cell degeneration. Using a model organism, zebrafish, the study aims to understand how these molecules interact and influence the health of the central nervous system. By examining genetic pathways, the researchers hope to uncover new insights into the mechanisms that regulate both astrocyte morphology and axon degeneration, which could lead to better understanding of neurodegenerative disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative conditions or those at risk for such disorders.
Not a fit: Patients with acute neurological injuries or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating degenerative neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Monk, Kelly R — Oregon Health & Science University
- Study coordinator: Monk, Kelly R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.