Investigating how certain molecules affect blood vessel health in heart disease
Novel Transcriptional & Post-Transcriptional Regulators of Endothelial Metabolism in Atherosclerosis
This study is looking at how certain tiny molecules affect the health of the cells lining your blood vessels, with the goal of finding new ways to help lower cholesterol and reduce inflammation, which can help prevent heart disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10886027 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific molecules, known as microRNAs and receptors, in the metabolism of endothelial cells, which line blood vessels. It aims to uncover how these molecules influence cholesterol levels and inflammation, both of which are critical in the development of atherosclerosis, a condition that can lead to heart disease. By studying the effects of microRNA-33 and Liver X Receptor on endothelial metabolism, the research seeks to identify potential targets for new treatments that could slow or prevent the progression of cardiovascular disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis, including those with high cholesterol, diabetes, or a family history of cardiovascular disease.
Not a fit: Patients who do not have risk factors for atherosclerosis or existing cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Citrin, Kathryn — Yale University
- Study coordinator: Citrin, Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.