Investigating how certain immune cells affect heart disease
The role of GATA3-positive macrophages in cardiovascular pathologies
This study is looking at a special type of immune cell called GATA3-positive macrophages to see how they affect heart problems like heart attacks, with the hope of finding better ways to treat or manage heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10877737 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of GATA3-positive macrophages, a type of immune cell, in cardiovascular diseases such as heart attacks. By utilizing advanced single-cell technologies, the study aims to explore how these macrophages contribute to inflammation and plaque instability in the arteries. The researchers will investigate the mechanisms that regulate the behavior of these macrophages, particularly after an acute myocardial infarction, to determine their impact on heart function. This could lead to new insights into how to better manage or treat heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced an acute myocardial infarction or are at high risk for cardiovascular diseases.
Not a fit: Patients with stable cardiovascular conditions or those without a history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart function and reduce the risk of heart attacks for patients.
How similar studies have performed: Other research has shown promise in understanding immune cell roles in cardiovascular diseases, but the specific focus on GATA3-positive macrophages is relatively novel.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Shah, Prediman Krishan — Cedars-Sinai Medical Center
- Study coordinator: Shah, Prediman Krishan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.