Investigating how certain brain signals affect binge drinking behavior
Prelimbic somatostatin peptide signaling in binge ethanol consumption
['FUNDING_R01'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11036363
This study is looking at how certain brain cells might affect binge drinking, with the goal of finding new ways to help people who struggle with alcohol use.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11036363 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the neurobiology behind binge drinking, particularly how somatostatin-expressing neurons in the prelimbic cortex influence alcohol consumption behaviors. By using advanced techniques like electrophysiology and circuit mapping, the study aims to uncover how these neurons can be targeted to prevent binge drinking. The research will explore the effects of somatostatin signaling on brain circuits and behavior in both normal conditions and during binge drinking episodes. This could lead to new therapeutic strategies for individuals struggling with alcohol use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who struggle with binge drinking or alcohol use disorder.
Not a fit: Patients who do not engage in binge drinking or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically prevent binge drinking and improve outcomes for individuals with alcohol use disorder.
How similar studies have performed: Previous research has shown promise in targeting neurobiological pathways for treating alcohol use disorders, suggesting that this approach could yield significant insights.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROWLEY, NICOLE ASHLEY — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: CROWLEY, NICOLE ASHLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders, alcohol use disorder