Investigating how certain bacteria produce substances that fight infections
Genetic basis of metabolite production against clinically-derived pathogens
This study is looking at how certain bacteria from the environment can help create new antibiotics to fight tough infections, especially for people dealing with antibiotic resistance, which has become an even bigger problem during the COVID-19 pandemic.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bowling Green State University NIH-funded |
| Lab location | 1 site (Bowling Green, United States) |
| Project ID | NIH-10796488 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic mechanisms behind the production of metabolites by environmental strains of bacteria, particularly those that can combat multi-drug resistant (MDR) pathogens. By exploring the genetic diversity of these bacteria, the research aims to identify new anti-infective agents that could be effective against difficult-to-treat infections. Patients may benefit from this research as it seeks to develop novel antibiotics that can address the growing threat of antibiotic resistance, especially in the context of infections exacerbated by the COVID-19 pandemic.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by multi-drug resistant bacteria, particularly those with conditions like cystic fibrosis.
Not a fit: Patients with infections that are not caused by multi-drug resistant bacteria may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by multi-drug resistant bacteria.
How similar studies have performed: Other research has shown promise in discovering new antibiotics from environmental bacteria, indicating that this approach could yield significant results.
Where this research is happening
Bowling Green, United States
- Bowling Green State University — Bowling Green, United States (Active)
Researchers
- Principal investigator: Wildschutte, Hans — Bowling Green State University
- Study coordinator: Wildschutte, Hans
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.